Has there been a #16 over a #1 upset, ever?

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what do you live under a rock ? the whole fricking world knows it's never happened. go on , beat it !
 

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But when there were only 48 teams, DePaul, as a number 1, lost to the bottom ranked team, then a number 12. Million years ago. Ray Meyer was the coach. Future NBA players on the team. Don't recall who they lost to without Googling it.
 

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Harvard over Stanford at Stanford

BeaverBall
 

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But when there were only 48 teams, DePaul, as a number 1, lost to the bottom ranked team, then a number 12. Million years ago. Ray Meyer was the coach. Future NBA players on the team. Don't recall who they lost to without Googling it.

Lost to St Josephs. DePaul was loaded also. I believe Mark Aguirre threw his uniform in the river after the game.
 

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