There was a guy that use to post 1st innings only and did quite well. Apparantly he showed a statistic (I dont know what it was exactly) but 1st innings score YES was at 47% (or maybe it was higher) of the time and you usually if not all the time get it at plus money. In any case his point was to find games that there was a good chance of first inning scoring.
In regards to the two good pitchers pitching place no, always stay away from this during the first quarter of the MLB season. You'll usually see a lot of good aces start slow, building up their arm strength during the season and they tend to not pitch as well. Case in point, Bumgarner, Kluber, Archer, Greinke, etc.