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Tiny Amounts of Nicotine Produce Startling Results in Endovasc Mouse Study


MONTGOMERY, Texas--(BUSINESS WIRE)--June 2, 2003--Endovasc Inc. (OTCBB:EVSC) announced a three-week study of 34 mice divided into two equal groups, one of which had tiny amounts of nicotine in the drinking water; the other had plain water. Both groups received the same chow and water freely.

The mice exercised on a treadmill (15 minutes) each day or until exhaustion. At the end of one week, the nicotine mice demonstrated a mean 1.25 mm increase over base line thigh girth; the water-only group or the control group showed a 0.28 mm increase in thigh girth diameter. At week two, the nicotine group demonstrated 3.41 mm increase in thigh girth; the control group only showed a 2.83 mm increase. After the three weeks, the nicotine group had stabilized a mean 2.32 mm thigh girth increase and the control group at 0.33 mm diameter increase or a mean average of 142% over the control (p is less than 0.05).

Interestingly, at the end of the study the body weight between the two groups showed the nicotine mice weighed an average of 18.3 grams less than the control group (42.14 grams vs 60.44 grams). Total food consumption for the control group was a mean 194.76 grams per mouse, but the nicotine group consumed a mean average of 10.24 grams less (184.50 grams) per mouse during the three-week period.

The company concluded that tiny amounts of nicotine appear to produce increase in muscle girth, decrease in body weight and reduction in appetite. Endovasc is running a second study to determine the amounts of leptin (an appetite hormone) in the blood of the nicotine mice compared to the control mice. Results will be public in approximately six weeks.

Endovasc has formed a nutraceutical company called Nutraceutical Development Corporation (NDC) to market its nutraceutical products. This study is to be used in the development of NDC's next new product.

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