Everybody has their own expertise/interest
but, in general, all things being equal, NCAA football certainly ranks an easier game to handicap than the NFL IMHO.
Why?
There are so many more variables in the college game to be considered and, therefore, more areas for the astute handicapper to find edges, including: talent disparity; scheduling; emotion; travel; etc.
In the NFL, the teams are relatively close in terms of pure athletic talent and coaching that it becomes more difficult for the handicapper to find edges in their analysis.
Evidence: The run-and-shoot and similar gimmick offenses will work for periods of time in the college game until the coaches "catch up" to ti. Do not try it in the NFL, however, because defenses are largely comprised of talented professionals whose "technique" is not easily compromised.
"Tricks are for kids." Or in this case, the college game.