49ers have been money at home in preseason and regular season so far. But this is a major mismatch. First, 49ers will be breaking in rookie quarterback in first start going against a defense who has been best in league not giving up more than 10 pts in any game. Second, no rivalry or bad blood to pump up 49ers. Third, their secondary is down to 2nd and 3rd stringers vs Big 3 of Colts is going to be comical as they could not stop McCown,Fitzgerald,Bouldin,and Johnson how are they going to stop this team with a hungry Manning looking to build up his stats from a slow start to the year. Fourth, prior to this game, 49ers have not given up less than 25 points in any game so far. Last, in game in Wk 2 vs similar caliber team in Philadelphia Eagles and got outclassed and pummeled by a 42-3 score. This will be a very similar game. I don't like to lay 14 in NFL but this one is too good to pass up. Any thoughts?