Money no object, I would own an Alienware.
Alienware’s Silent Liquid Cooling technology includes a number of key features for added safety and reliability:
Dual-pump design provides redundancy for enhanced long-term reliability
Uses built-in, three-speed fan control for the quietest operation possible
Reduces dust accumulation on internal components, resulting in a longer lifespan and cleaner overall system
Proprietary power control board constantly monitors liquid temperature, with emergency alarm and automatic shut down features
CPU retention clip places even pressure across the CPU for extra protection