Wife and I stay at "The Hotel" regularly, and we live in Vegas. All suites, two plasma TV's, nice living room, even have a LCD TV in bathroom. Easy Valet and nice to be away from the Casino, yet very easy access. Close to sportsbook and poker room too.
Harrington, if you've never been to Vegas and price is no issue, you probably won't go wrong at Wynn. They have good restaurants there and I hear the rooms are great. It is at the north end of the strip so you will have a good walk to Bellagio, but between Mirage and Wynn are Venitian, Caesars, Mirage, TI, and Fashion Show Mall is across the street from Wynn. Mirage, NYNY, Mandalay Bay are definitely a Taxi ride.
I suggest taking the wife to Mix, a lounge at the top of "The Hotel" at Mandalay Bay, best view of LV and great outdoor patio. Tons of great restaurants near your location, in fact the steakhouse in Wynn was just voted the best steakhouse in LV by some local rag. there is a good thai restaurant in Wynn too. Other great restaurants nearby are Boa, Roku (sushi), Olive, Delmonico, Prime, Joe's Steak and Crab, Spago (good for lunch if the wife is shopping), Michaels if you want to spend $$$$$, Social House at TI is excellent food too. Two restaurants to avoid, Fix (Bellagio) and Stack (Mirage)....lots of poser wannabes, average food, and shit service.
And don't forget to stop in and say hi to Green Doberman at I.P. Have fun!