There is no right or wrong answer to this but in football I try and grab key numbers and espically when the number is at it's apex.
Good example was last nite game. All week the line hovered around 6.5/7, I decided that if and when the line went thru the key number 7 and hit +7.5 I would pull the trigger (doing it last nite is a whole different story). Grabbing key numbers and catching lines at their apex means everything when betting, it is way more important than handicapping a game.
Each sport or bet has different rules for me to pull thr trigger on a play but I like to find the consenesus number on a game and bet the game if the number is off when zero handicapping involved. You do that enough times you will win.