The name Zzyzx, was given to the area in 1944 by Curtis Howe Springer, claiming it to be the last word in the English language. Springer made up the word's pronunciation. He established the Zzyzx Mineral Springs and Health Spa at the spot, which was federal land that he had no permission to use. He used the springs to bottle his water and provide drinks for travelers through the hot desert. Curtis also imported animals from around the country to attract more families to visit his ranch. He used Zzyzx until 1974, when he was arrested by the United States Marshals for misuse of the land as well as alleged violations of food and drug laws, and the land was reclaimed by the government.
Since 1976, the Bureau of Land Management has allowed California State University to manage the land in and around Zzyzx. A consortium of CSU campuses use it as their Desert Studies Center.