In terms of win-loss records, the American League posted a 134-118 record in Interleague Play in 2010. The 2010 season marked the seventh consecutive year in which the A.L. earned the edge in the season series, extending its all-time advantage to 1,808-1,652 (.523). The A.L. went 127-125 in 2004, 136-116 in 2005, 154-98 in 2006, 137-115 in 2007, 149-103 in 2008 and 138-114 in 2009 before the 134-118 mark last year.
In 2010, A.L. Clubs compiled a .269 batting average with 233 home runs, 1,168 runs scored and a 4.16 ERA. N.L. Clubs batted .251 with 242 home runs, 1,098 runs scored and a 4.37 ERA. The Chicago White Sox posted the best record in Interleague play in 2010 at 15-3 (.833), followed by the Texas Rangers at 14-4 (.778) and the Boston Red Sox and New York Mets, each at 13-5 (.722). The New York Yankees hold MLB’s best all-time Interleague record at 144-102 (.585), followed by the White Sox at 143-104 (.579).
The Florida Marlins own the N.L.’s best all-time Interleague mark at 127-107 (.543)
In 2010, A.L. Clubs compiled a .269 batting average with 233 home runs, 1,168 runs scored and a 4.16 ERA. N.L. Clubs batted .251 with 242 home runs, 1,098 runs scored and a 4.37 ERA. The Chicago White Sox posted the best record in Interleague play in 2010 at 15-3 (.833), followed by the Texas Rangers at 14-4 (.778) and the Boston Red Sox and New York Mets, each at 13-5 (.722). The New York Yankees hold MLB’s best all-time Interleague record at 144-102 (.585), followed by the White Sox at 143-104 (.579).
The Florida Marlins own the N.L.’s best all-time Interleague mark at 127-107 (.543)