Tonights winning Pick 4 Lottery numbers in SC were 2222. According to the website some 652 people had a straight winner of a minimum of $2500 on a .50 cent ticket. Some people did indeed of course have a $1 ticket for $5000 but for arguement purposes as most tickets purchased are only for .50 cents for a $2500 payday, the total payout by the Lottery Commission would be is $1.630,000. The guy that spent that extra fifty cents is $2500 richer for his efforts tonight.